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Activation of the farnesoid X receptor (FXR), a ligand‐activated nuclear hormone receptor that is a key regulator of bile acid homeostasis, has demonstrated clinical benefit in patients with PSC, as shown by the sustained reduction in serum alkaline phosphatase levels induced by multiple FXR agonists, including obeticholic acid in a phase 2 trial (NCT02177136)
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Size:50 Grams (1.8 oz)
Surrounding fibroblasts and macrophages share with tumor cells the ability to release proteolytic enzymes, like metalloproteinases (MMPs), elastase and trypsin, which degrade extracellular matrix and cause abnormal blood vessel permeability [36,37,38]